Interaction with other medicines
The antibiotic interacts with a number of drugs:
- clindamycin is not compatible with barbiturates, ampicillin, calcium gluconate, magnesium sulfate and aminophylline. The joint use of drugs is prohibited;
- is an antagonist of erythromycin;
- increased risk of toxic effects on the kidneys when interacting with Fortum;
- enhances the action of aminoglycosides - streptomycin, gentamicin, rifampicin;
- it is forbidden to combine clindamycin with antidiarrheal drugs. https://perfecthealthus.com/where-can-i-buy-clindamycin-300mg-150mg-clindamycin-hydrochloride-without-prescription/ This complicates the withdrawal of the substance, among other things, and can lead to the appearance of pseudomembrane colitis;
- when combined with opiate analgesics causes respiratory depression;
- with intravaginal administration, it is not recommended to combine with any other drugs of a similar action.
Clindamycin is not compatible with alcohol. During treatment and after a few more weeks, you can not drink alcohol.
Incompatible with solutions containing a complex of B vitamins, aminoglycosides, ampicillin, phenytoin, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.
Taking the drug is antagonistic with erythromycin and chloramphenicol..
Enhances the effect of competitive muscle relaxants.
With simultaneous use with opioid (narcotic) analgesics, it is possible to increase the respiratory depression caused by them (up to apnea).
Simultaneous administration with antidiarrheal drugs that reduce gastrointestinal motility increases the risk of pseudomembranous colitis.
Aminoglycosides expand the spectrum of antimicrobial action; enhances (mutually) the effect of rifampicin.
After oral administration, clindamycin is rapidly and almost completely (90%) absorbed. http://www.medicinenet.com/clindamycin-oral/article.htm From 40 to 90% of the dose binds to proteins. No oral accumulations have been identified. Clindamycin easily penetrates into body fluids and tissues: bone tissue, breast milk, synovial fluid, sputum, peritoneal fluid, fetal blood, manure, pleural fluid. Clindamycin does not penetrate into the cerebrospinal fluid even with meningitis. The half-life of clindamycin is approximately 1.5-3.5 hours. It is somewhat longer in patients with significantly reduced liver or kidney function. With moderately severe impaired renal or hepatic function, dosage adjustment is not necessary. Clindamycin is relatively extensively metabolized. 10-20% of the drug in the form of a microbiologically active substance is excreted in the urine, 4% - with feces. The rest is excreted as inactive metabolites. It is excreted mainly with bile and feces..